Many of the readings come from the course textbook, "Brock": Madigan, Michael, and John Martinko. Brock Biology of Microorganisms. 11th ed. Upper Saddle River, NJ: Pearson Prentice Hall, 2005. ISBN: 9780131443297.
| LEC # | TOPICS | LECTURERS | READINGS |
|---|---|---|---|
| 1 | Early Earth/Microbial Evolution | Prof. Ed DeLong | Chapter 11 in Brock |
| 2 | Cell Structure/Function | Prof. Ed DeLong | Chapter 4 in Brock |
| 3 | Biological Energy Conservation | Prof. Ed DeLong | Chapters 5 and 17 in Brock |
| 4 | Microbial Growth | Prof. David Schauer | Chapter 6 in Brock |
| 5 | Metabolic Regulation | Prof. Ed DeLong | |
| 6 | Virology | Prof. David Schauer | Chapter 9 in Brock |
| 7 | Information Flow in Biological Systems | Prof. Ed DeLong | Chapter 10 in Brock |
| Midterm I | |||
| 8 | Regulation of Cell Activity | Prof. Ed DeLong | Chapter 8 in Brock |
| 9 | Genetic Exchange in Bacteria | Prof. Ed DeLong | |
| 10 | Experimental Evolution: Optimization of Metabolic Systems | Guest Lecturer, Prof. Christopher Marx from Harvard | Marx, Christopher J., Stephen J. Van Dien, and Mary E. Lidstrom. "Flux Analysis Uncovers Key Role of Functional Redundancy in Formaldehyde Metabolism." PLOS Biology 3 (2005): 244-253. (PDF) |
| 11 | Genomics I | Prof. Ed DeLong | Chapter 15 in Brock |
| 12 | Genomics II | Prof. Ed DeLong | Chapter 15 in Brock |
| 13 | Metabolic Diversity I | Prof. Ed DeLong | Chapter 17 in Brock |
| 14 | Metabolic Diversity II | Prof. Ed DeLong | Chapter 17 in Brock |
| 15 | Microbial Ecology | Prof. Ed DeLong | Chapter 19 in Brock |
| Midterm II | |||
| 16 | Microbial Growth Control | Prof. David Schauer | Chapter 20 in Brock |
| 17 | Microbe-host Interactions | Prof. David Schauer |
Chapter 21 in Brock Backhed, Fredrik, et al. "Host-Bacterial Mutualism in the Human Intestine." Science 307 (2005): 1915-1920. |
| 18 | Immunology I | Megan McBee | Chapters 22 and 23 in Brock |
| 19 | Immunology II | Megan McBee | |
| 20 | Diagnostic Microbiology | Prof. David Schauer | Chapters 21 and 24 in Brock |
| 21 | Person-to-person Transmission | Prof. David Schauer | Chapter 25 in Brock |
| 22 | Epidemiology | Megan McBee | Chapter 26 in Brock |
| 23 | Animal- and Arthropod-transmitted Diseases | Prof. David Schauer | Chapter 27 in Brock |
| 24 | Review | Prof. David Schauer | Chapters 28 and 29 in Brock |
| Final Exam |
Other Readings
Backhed, Fredrik, et al. "Host-Bacterial Mutualism in the Human Intestine." Science 307 (2005): 1915-1920.
Berg, Howard. "Motile Behavior of Bacteria." Physics Today on the Web (January 2000).
Galan, Jorge E., and Hans Wolf-Watz. "Protein Delivery into Eukaryotic Cells by Type III Secretion Machines." Nature 444 (2006): 567-573.
Jetten, Mike S. M., et al. "Microbiology and Application of the Anaerobic Ammonium Oxidation (‘Anammox’) Process." Environmental Biotechnology 12 (2001): 283-288.
Lovley, Derek R. "Bug Juice: Harvesting Electricity with Microorganisms." Nature Reviews Microbiology 4 (2006): 497-508.
Marx, Christopher J., Stephen J. Van Dien, and Mary E. Lidstrom. "Flux Analysis Uncovers Key Role of Functional Redundancy in Formaldehyde Metabolism." PLOS Biology 3 (2005): 244-253. (PDF)
Moran, Nancy A., Fordon R. Plague, Jonas P. Sandstro, and Jennifer L. Wilcox. "A Genomic Perspective on Nutrient Provisioning by Bacterial Symbionts of Insects." PNAS 100 (2003): 14543-14548.
Nakabachi, Atsushi, et al. "The 160-Kilobase Genome of the Bacterial Endosymbiont Carsonella." Science 314 (2006): 267.
Pace, Norman R. "Time for a Change." Nature 441 (2006): 289.
Purcell, E. M. "Life at Low Reynolds Number." American Journal of Physics 45 (1977): 3-11.
Santiago, F. Elena, and Richard E. Lenski. "Evolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation." Nature Reviews Genetics 4 (2003): 457-469.
Tamas, Ivica, et al. "50 Million Years of Genomic Stasis in Endosymbiotic Bacteria." Science 296 (2002): 2376-2379.
Wu, Dongying, et al. "Metabolic Complementarity and Genomics of the Dual Bacterial Symbiosis of Sharpshooters." PLOS Biology 4 (2006): 1079-1092. (PDF - 1.0 MB)